THE HUMAN CYTOMEGALOVIRUS MAJOR IMMEDIATE-EARLY PROTEINS AS ANTAGONISTS OF INTRINSIC AND INNATE ANTIVIRAL HOST RESPONSES

The major immediate-early (IE) gene of human cytomegalovirus (CMV) is believed to have a decisive role in acute infection and its activity is an important indicator of viral reactivation from latency.Although a variety of gene products are expressed from this region, the 72-kDa IE1 and the 86-kDa Tote Bag IE2 nuclear phosphoproteins are the most ab

Introduction 2021 Global Initiative for Chronic Obstructive Lung Disease (GOLD) Reports recommends that patients with clinically significant symptoms and exacerbations of chronic obstructive pulmonary disease (COPD) should escalate to triple therapy, a combined use of inhaled corticosteroids (ICS), long-acting muscarinic antagonists (LAMA) and long